In an October issue of Toxicology, researchers at Imperial College London shared results of a study treating human breast cancer cell lines with PhIP—one of a group of carcinogens called “heterocyclic animes.” PhIP can be found in many grilled and barbecued meats, but it is more prevalent in chicken.
Throughout their studies, researchers found that even very small doses of PhIP caused cells to exhibit extracellular invasive behavior, although this invasiveness continued to surge following increased dosages.
Astonishingly, some doses of PhIP surpassed even the positive control, 17B-estradiol, the most common form of estrogen and a major promoter of breast cancer cells. This could mean that not only is PhIP a breast cancer culprit because of its ability to damage DNA, it also increases the chances of worsening the existing disease.
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Posted by Jason Baker